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Nature Immunology 9, 713 - 714 (2008)
doi:10.1038/ni0708-713
New dimensions of CIITA
Walter Reith1 & Jeremy M Boss2
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Walter Reith is in the Department of Pathology and Immunology, University of Geneva Medical School, CH-1211 Geneva, Switzerland.
e-mail: walter.reith@medecine.unige.ch - Jeremy M. Boss is in the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Abstract
CIITA encodes the 'master regulator' of the expression of major histocompatibility complex class II genes. A new layer of complexity has been identified in the control of CIITA expression, which involves the formation of a complex three-dimensional chromatin structure promoted by interactions among many distant regulatory elements.
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