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From the following article

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

Sebastian Herzog, Eva Hug, Sonja Meixlsperger, Ji-Hye Paik, Ronald A DePinho, Michael Reth & Hassan Jumaa

Nature Immunology 9, 623 - 631 (2008) Published online: 18 May 2008

doi:10.1038/ni.1616

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Figure 1

Signaling through PI(3)K and PKB regulates light chain recombination in pre-B cells.

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Figure 2

PKB targets Foxo3a in pre-B cells.

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Figure 3

Foxo3a-A3 promotes differentiation of pre-B cells.

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Figure 4

Foxo3a-A3 prolongs the G1 phase of the cell cycle and stabilizes RAG-2.

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Figure 5

Foxo3a-A3 counteracts the block in kappa light chain expression in pre-B cells mediated by constitutively active PKB.

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Figure 6

Foxo3a-deficient pre-B cells show impaired differentiation into BCR+ cells in vitro.

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Figure 7

SLP-65 activates Foxo3a and Foxo1 in pre-B cells by counteracting PKB.

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Figure 8

SLP-65 signaling regulates the PI(3)K-PKB-Foxo3a pathway in BCR+ cells.

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