News and Views
Nature Immunology 9, 586 - 588 (2008)
doi:10.1038/ni0608-586
Foxos around make B cells tolerable
Marta A W Rowh1 & Craig H Bassing1
- Marta A.W. Rowh and Craig H. Bassing are in the Immunology Graduate Group, Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. e-mail: bassing@email.chop.edu
Abstract
B cell tolerance is achieved in part through secondary rearrangements that replace ('edit') exons encoding autoreactive antigen-receptor chains. New findings suggest that Foxo transcription factors are critical regulators of receptor editing by activating the transcription of recombination-activating genes.
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