News and Views
Nature Immunology 9, 583 - 584 (2008)
doi:10.1038/ni0608-583
CD3 ITAMs count!
Bernard Malissen1
- Bernard Malissen is at the Centre d'Immunologie de Marseille–Luminy, Université de la Méditerrannée, INSERM U631, CNRS UMR6102, 13288 Marseille Cedex 9, France. e-mail: bernardm@ciml.univ-mrs.fr
Abstract
The T cell receptor (TCR) is functionally coupled to a constellation of ten immunoreceptor tyrosine–based activation motifs (ITAMs). A new study suggests that this large number of ITAMs is mandatory for preventing autoimmunity.
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