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'Fine tuning' TLR signaling

Nature Immunology volume 9, pages 459–461 (2008)Cite this article

Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.

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Figure 1: SHP-1 targets IRAK1 to decrease tumor necrosis factor and potentiate IFN-β production.

Kim Caesar

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  1. Luke A.J. O'Neill is with the School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. laoneill@tcd.ie,

    Luke A J O'Neill

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  1. Luke A J O'Neill
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O'Neill, L. 'Fine tuning' TLR signaling. Nat Immunol 9, 459–461 (2008). https://doi.org/10.1038/ni0508-459

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