Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cross-presentation: avoiding trafficking chaos?

Cross-presentation of antigens is essential for the responses of cytotoxic T cells to tumors and viruses. Two new papers offer insights into the subcellular compartment and types of dendritic cells that mediate cross-presentation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Three models of cross-presentation.

Kim Caesar

References

  1. Bevan, M.J. J. Exp. Med. 143, 1283–1288 (1976).

    Article  CAS  Google Scholar 

  2. Bevan, M.J. Nat. Immunol. 7, 363–365 (2006).

    Article  CAS  Google Scholar 

  3. Burgdorf, S. et al. Nat. Immunol. 9, 558–566 (2008).

    Article  CAS  Google Scholar 

  4. Di Pucchio, T. et al. Nat. Immunol. 9, 551–557 (2008).

    Article  CAS  Google Scholar 

  5. Lin, M.L., Zhan, Y., Villadangos, J.A. & Lew, A.M. Immunol. Cell Biol. advance online publication 12 February 2008 (doi:10.1038/icb.2008.3).

    Article  CAS  Google Scholar 

  6. Gagnon, E. et al. Cell 110, 119–131 (2002).

    Article  CAS  Google Scholar 

  7. Touret, N. et al. Cell 123, 157–170 (2005).

    Article  CAS  Google Scholar 

  8. Ackerman, A.L., Kyritsis, C., Tampe, R. & Cresswell, P. Proc. Natl. Acad. Sci. USA 100, 12889–12894 (2003).

    Article  CAS  Google Scholar 

  9. Guermonprez, P. et al. Nature 425, 397–402 (2003).

    Article  CAS  Google Scholar 

  10. Houde, M. et al. Nature 425, 402–406 (2003).

    Article  CAS  Google Scholar 

  11. Lakadamyali, M., Rust, M.J. & Zhuang, X. Cell 124, 997–1009 (2006).

    Article  CAS  Google Scholar 

  12. Burgdorf, S., Kautz, A., Bohnert, V., Knolle, P.A. & Kurts, C. Science 316, 612–616 (2007).

    Article  CAS  Google Scholar 

  13. den Haan, J.M., Lehar, S.M. & Bevan, M.J. J. Exp. Med. 192, 1685–1696 (2000).

    Article  CAS  Google Scholar 

  14. Hoeffel, G. et al. Immunity 27, 481–492 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kasturi, S., Pulendran, B. Cross-presentation: avoiding trafficking chaos?. Nat Immunol 9, 461–463 (2008). https://doi.org/10.1038/ni0508-461

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0508-461

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing