Perspective abstract


Nature Immunology 9, 486 - 494 (2008)
Published online: 18 April 2008 | doi:10.1038/ni1580

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

Magali Terme1,2, Evelyn Ullrich1,2, Nicolas F Delahaye1,2, Nathalie Chaput2,3 & Laurence Zitvogel1,2,3,4


Natural killer (NK) cells influence innate and adaptive immune host defenses. Existing data indicate that manipulating the balance between inhibitory and activating NK receptor signals, the sensitivity of target cells to NK cell-mediated apoptosis, and NK cell cross-talk with dendritic cells might hold therapeutic promise. Efforts to modulate NK cell trafficking into inflamed tissues and/or lymph nodes, and to counteract NK cell suppressors, might also prove fruitful in the clinic. However, deeper investigation into the benefits of combination therapy, greater understanding of the functional distinctions between NK cell subsets, and design of new tools to monitor NK cell activity are needed to strengthen our ability to harness the power of NK cells for therapeutic aims.

Top
  1. INSERM, U805, Institut Gustave Roussy, Institut Gustave Roussy, 39 Rue Camille Desmoulins, F-94805 Villejuif, Paris, France.
  2. Institut Gustave Roussy, Institut Gustave Roussy, 39 Rue Camille Desmoulins, F-94805 Villejuif, Paris, France.
  3. Centres d'Investigation Cliniques BT507, Institut Gustave Roussy, 39 Rue Camille Desmoulins, F-94805 Villejuif, Paris, France.
  4. Faculté de Médecine Paris Sud-Université Paris XI, 63 rue Gabriel Péri, 94276 Le Kremlin Bicêtre Cedex, France.

Correspondence to: Laurence Zitvogel1,2,3,4 e-mail: zitvogel@igr.fr



MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Signaling for cytotoxicity

Nature Immunology News and Views (01 Nov 2000)