News and Views
Nature Immunology 9, 459 - 461 (2008)
doi:10.1038/ni0508-459
'Fine tuning' TLR signaling
Luke A J O'Neill1
-
Luke A.J. O'Neill is with the School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
e-mail: laoneill@tcd.ie
Abstract
Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
New DNA-sensing pathway feeds RIG-I with RNANature Immunology News and Views (01 Oct 2009)
DisSARMing Toll-like receptor signalingNature Immunology News and Views (01 Oct 2006)
See all 6 matches for News And ViewsRESEARCH
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1Nature Immunology Article (01 May 2008)
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferonNature Immunology Article (01 Jul 2009)
See all 37 matches for Research
