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Nature Immunology 9, 455 - 457 (2008)
doi:10.1038/ni0508-455
Moving out: mobilizing activated T cells from lymphoid tissues
Gabriel Berstein1 & Robert T Abraham2
- Gabriel Berstein is with Inflammation Discovery Research, Wyeth, Cambridge, Massachusetts 02140, USA.
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Robert T. Abraham is with Oncology Discovery Research, Wyeth, Pearl River, New York 10960, USA.
e-mail: abrahar@wyeth.com
Abstract
The intensity of cytokine-induced signaling by the kinase PI(3)K subunit p110
proves to be an important regulator of T cell migration patterns. High PI(3)K activity functions through the nutrient and bioenergetic sensor mTOR to modulate the transcription factor KLF2 and thereby the repertoire of tissue-homing receptors expressed on effector T cells.
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RESEARCH
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte traffickingNature Immunology Article (01 May 2008)
