The homing of lymphocytes to secondary lymphoid organs occurs at specialized blood vessels, the high endothelial venules. Autotaxin, a phospholipid-producing enzyme secreted by high endothelial venule endothelium, is a new participant found to facilitate the entry of lymphocytes into secondary lymphoid organs.
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Vestweber, D., Wild, M. A new player in lymphocyte homing. Nat Immunol 9, 347–348 (2008). https://doi.org/10.1038/ni0408-347
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DOI: https://doi.org/10.1038/ni0408-347