Abstract

Beyond its established function in hematopoiesis, the bone marrow hosts mature lymphocytes and acts as a secondary lymphoid organ in the initiation of T cell and B cell responses. Here we report the characterization of bone marrow–resident dendritic cells (bmDCs). Multiphoton imaging showed that bmDCs were organized into perivascular clusters that enveloped blood vessels and were seeded with mature B lymphocytes and T lymphocytes. Conditional ablation of bmDCs in these bone marrow immune niches led to the specific loss of mature B cells, a phenotype that could be reversed by overexpression of the antiapoptotic factor Bcl-2 in B cells. The presence of bmDCs promoted the survival of recirculating B cells in the bone marrow through the production of macrophage migration–inhibitory factor. Thus, bmDCs are critical for the maintenance of recirculating B cells in the bone marrow.

1. Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
2. Department of Veterinary Resources, The Weizmann Institute of Science, Rehovot 76100, Israel.
3. These authors contributed equally to this work.

Correspondence to: Steffen Jung^1,3 e-mail: s.jung@weizmann.ac.il

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