News and Views
Nature Immunology 9, 348 - 350 (2008)
doi:10.1038/ni0408-348
TRIM-ing down Tolls
Andrew G Bowie1
- Andrew G. Bowie is with the School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. e-mail: agbowie@tcd.ie
Abstract
Activation of the transcription factor NF-
B by Toll-like receptors must be controlled to avoid excessive inflammation. The tripartite-motif protein family member TRIM30
has now been shown to mediate a negative regulatory feedback mechanism curtailing such responses.
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