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Nature Immunology 9, 347 - 348 (2008)
doi:10.1038/ni0408-347
A new player in lymphocyte homing
Dietmar Vestweber1 & Martin K Wild1
- Dietmar Vestweber & Martin K. Wild are in the Department of Vascular Cell Biology, Max-Planck Institute for Molecular Biomedicine, D-48149 Münster, Germany. e-mail: vestweb@mpi-muenster.mpg.de e-mail: mwild@mpi-muenster.mpg.de
Abstract
The homing of lymphocytes to secondary lymphoid organs occurs at specialized blood vessels, the high endothelial venules. Autotaxin, a phospholipid-producing enzyme secreted by high endothelial venule endothelium, is a new participant found to facilitate the entry of lymphocytes into secondary lymphoid organs.
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Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organsNature Immunology Article (01 Apr 2008)
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