Table of contents


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Editorials

Through the Signaling Gateway p331

doi:10.1038/ni0408-331a


Immunology around the world p331

doi:10.1038/ni0408-331b


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Obituary

Frank J. Dixon 1920–2008 p333

Michael B A Oldstone

doi:10.1038/ni0408-333


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Essay

A memoir of AID, which engraves antibody memory on DNA pp335 - 337

Tasuku Honjo

doi:10.1038/ni0408-335


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Commentary

Immunology in China: the past, present and future pp339 - 342

Xuetao Cao

doi:10.1038/ni0408-339


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News and Views


New niches for B cells pp345 - 346

Takashi Nagasawa

doi:10.1038/ni0408-345

See also: Article by Sapoznikov et al.


A new player in lymphocyte homing pp347 - 348

Dietmar Vestweber & Martin K Wild

doi:10.1038/ni0408-347

See also: Article by Kanda et al.


TRIM-ing down Tolls pp348 - 350

Andrew G Bowie

doi:10.1038/ni0408-348

See also: Article by Shi et al.


Research Highlights p351

doi:10.1038/ni0408-351


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Review

Post-transcriptional control of cytokine production pp353 - 359

Paul Anderson

doi:10.1038/ni1584


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Articles

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta pp361 - 368

Jonathan C Kagan, Tian Su, Tiffany Horng, Amy Chow, Shizuo Akira & Ruslan Medzhitov

doi:10.1038/ni1569

See also: News and Views by Watts


TRIM30alpha negatively regulates TLR-mediated NF-kappaB activation by targeting TAB2 and TAB3 for degradation pp369 - 377

Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang & Bing Sun

doi:10.1038/ni1577

See also: News and Views by Bowie


TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes pp378 - 387

Anna Yarilina, Kyung-Hyun Park-Min, Taras Antoniv, Xiaoyu Hu & Lionel B Ivashkiv

doi:10.1038/ni1576


Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches pp388 - 395

Anita Sapoznikov, Yael Pewzner-Jung, Vyacheslav Kalchenko, Rita Krauthgamer, Idit Shachar & Steffen Jung

doi:10.1038/ni1571

See also: News and Views by Nagasawa


Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre–B cells pp396 - 404

Susannah L Hewitt, Deborah Farmer, Katarzyna Marszalek, Emily Cadera, Hong-Erh Liang, Yang Xu, Mark S Schlissel & Jane A Skok

doi:10.1038/ni1567


Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes pp405 - 414

Changchun Xiao, Lakshmi Srinivasan, Dinis Pedro Calado, Heide Christine Patterson, Baochun Zhang, Jing Wang, Joel M Henderson, Jeffrey L Kutok & Klaus Rajewsky

doi:10.1038/ni1575


Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs pp415 - 423

Hidenobu Kanda, Rebecca Newton, Russell Klein, Yuka Morita, Michael D Gunn & Steven D Rosen

doi:10.1038/ni1573

See also: News and Views by Vestweber & Wild


Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering pp424 - 431

Philipp Mueller, Jan Massner, Rajesh Jayachandran, Benoit Combaluzier, Imke Albrecht, John Gatfield, Carmen Blum, Rod Ceredig, Hans-Reimer Rodewald, Antonius G Rolink & Jean Pieters

doi:10.1038/ni1570


Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance pp432 - 443

Masatsugu Oh-hora, Megumi Yamashita, Patrick G Hogan, Sonia Sharma, Ed Lamperti, Woo Chung, Murali Prakriya, Stefan Feske & Anjana Rao

doi:10.1038/ni1574


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