Table of contents


cover image
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Editorial

Politicizing science no more p217

doi:10.1038/ni0308-217


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Commentary

Immunological outreach through positive selection pp219 - 221

Neil S Greenspan

doi:10.1038/ni0308-219


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News and Views

Basophils: in the spotlight at last pp223 - 225

Booki Min & William E Paul

doi:10.1038/ni0308-223

See also: Article by Sokol et al.


HIV's gut feeling pp225 - 227

Quentin Sattentau

doi:10.1038/ni0308-225

See also: Article by Arthos et al.


Itching to end NF-kappaB pp227 - 229

Vigo Heissmeyer & Anjana Rao

doi:10.1038/ni0308-227

See also: Article by Shembade et al.


How T cells 'find' the right dendritic cell pp229 - 230

Andrey S Shaw

doi:10.1038/ni0308-229

See also: Article by Henrickson et al.


Finally, MALT1 is a protease! pp231 - 233

Linda M McAllister-Lucas & Peter C Lucas

doi:10.1038/ni0308-231

See also: Article by Coornaert et al. | Article by Rebeaud et al.


Innocents abroad: regulating where naive T cells go pp233 - 235

Barrett J Rollins

doi:10.1038/ni0308-233

See also: Article by Sebzda et al.


Research Highlights p237

doi:10.1038/ni0308-237


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Review

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation pp239 - 244

Qizhi Tang & Jeffrey A Bluestone

doi:10.1038/ni1572


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Articles

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 pp245 - 253

K Venuprasad, Haining Huang, Yousuke Harada, Chris Elly, Malayannan Subramaniam, Thomas Spelsberg, Jin Su & Yun-Cai Liu

doi:10.1038/ni1564


The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 pp254 - 262

Noula Shembade, Nicole S Harhaj, Kislay Parvatiyar, Neal G Copeland, Nancy A Jenkins, Lydia E Matesic & Edward W Harhaj

doi:10.1038/ni1563

See also: News and Views by Heissmeyer & Rao


T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-kappaB inhibitor A20 pp263 - 271

Beatrice Coornaert, Mathijs Baens, Karen Heyninck, Tine Bekaert, Mira Haegman, Jens Staal, Lijun Sun, Zhijian J Chen, Peter Marynen & Rudi Beyaert

doi:10.1038/ni1561

See also: News and Views by McAllister-Lucas & Lucas | Article by Rebeaud et al.


The proteolytic activity of the paracaspase MALT1 is key in T cell activation pp272 - 281

Fabien Rebeaud, Stephan Hailfinger, Anita Posevitz-Fejfar, Myriam Tapernoux, Roger Moser, Daniel Rueda, Olivier Gaide, Montserrat Guzzardi, Emanuela M Iancu, Nathalie Rufer, Nicolas Fasel & Margot Thome

doi:10.1038/ni1568

See also: News and Views by McAllister-Lucas & Lucas | Article by Coornaert et al.


T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation pp282 - 291

Sarah E Henrickson, Thorsten R Mempel, Irina B Mazo, Bai Liu, Maxim N Artyomov, Huan Zheng, Antonio Peixoto, Michael P Flynn, Balimkiz Senman, Tobias Junt, Hing C Wong, Arup K Chakraborty & Ulrich H von Andrian

doi:10.1038/ni1559

See also: News and Views by Shaw


Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns pp292 - 300

Eric Sebzda, Zhiying Zou, John S Lee, Tao Wang & Mark L Kahn

doi:10.1038/ni1565

See also: News and Views by Rollins


HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells pp301 - 309

James Arthos, Claudia Cicala, Elena Martinelli, Katilyn Macleod, Donald Van Ryk, Danlan Wei, Zhen Xiao, Timothy D Veenstra, Thomas P Conrad, Richard A Lempicki, Sherry McLaughlin, Massimiliano Pascuccio, Ravindra Gopaul, Jonathan McNally, Catherine C Cruz, Nina Censoplano, Eva Chung, Kristin N Reitano, Shyam Kottilil, Diana J Goode & Anthony S Fauci

doi:10.1038/ni1566

See also: News and Views by Sattentau


A mechanism for the initiation of allergen-induced T helper type 2 responses pp310 - 318

Caroline L Sokol, Gregory M Barton, Andrew G Farr & Ruslan Medzhitov

doi:10.1038/ni1558

See also: News and Views by Min & Paul


Antibody responses of variable lymphocyte receptors in the lamprey pp319 - 327

Matthew N Alder, Brantley R Herrin, Andrea Sadlonova, Cecil R Stockard, William E Grizzle, Lanier A Gartland, G Larry Gartland, Jeremy A Boydston, Charles L Turnbough, Jr & Max D Cooper

doi:10.1038/ni1562


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Corrigenda

Corrigendum: Gene regulation mediated by calcium signals in T lymphocytes pp328 - 329

Stefan Feske, Jena Giltnane, Ricardo Dolmetsch, Louis M Staudt & Anjana Rao

doi:10.1038/ni0308-328


Corrigendum: Connecting immunology research to public health: Cuban biotechnology p329

Agustin Lage

doi:10.1038/ni0308-329


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