Article abstract
Nature Immunology 9, 292 - 300 (2008)
Published online: 3 February 2008 | doi:10.1038/ni1565
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
Eric Sebzda1,2, Zhiying Zou1, John S Lee1, Tao Wang1 & Mark L Kahn1
Abstract
The migration patterns of naive and activated T cells are associated with the expression of distinct sets of chemokine receptors, but the molecular basis for this regulation is unknown. Here we identify Krupple-like factor 2 (KLF2) as a key transcriptional factor needed to prevent naive T cells from expressing inflammatory chemokine receptors and acquiring the migration patterns of activated T cells. Lineage-specific deletion of KLF2 resulted in fewer naive T cells in the blood and secondary lymphoid organs, whereas it expanded naive T cell numbers in nonlymphoid tissues; these effects were associated with altered expression of inflammatory chemokine receptors on naive T cells. KLF2 repressed the expression of several chemokine receptors, including CCR3 and CCR5. We thus conclude that KLF2 maintains proper T cell migration patterns by linking T cell movement and transcriptional regulation of chemokine receptor expression patterns.
- Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
- Present address: Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA.
Correspondence to: Eric Sebzda1,2 e-mail: eric.sebzda@vanderbilt.edu
Correspondence to: Mark L Kahn1 e-mail: markkahn@mail.med.upenn.edu
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