1. Vigo Heissmeyer is with the Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Molecular Immunology, 81377 Munich, Germany. e-mail: vigo.heissmeyer@helmholtz-muenchen.de
2. Anjana Rao is in the Department of Pathology, Harvard Medical School, and Immune Disease Institute, Boston, Massachusetts 02115, USA.

Abstract

Both activation and termination of transcription factor NF-B signaling require ubiquitin modification of pathway components. The E3 ligase Itch teams up with the NF-B inhibitor A20 to edit the composition of ubiquitin chains on the signaling adaptor RIP, thereby limiting inflammatory responses.

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NPG Journals

by Subject Area

• Chemistry

  • Chemistry
  • Drug discovery
  • Biotechnology
  • Materials
  • Methods & Protocols

• Clinical Practice & Research

  • Cancer
  • Cardiovascular medicine
  • Dentistry
  • Endocrinology
  • Gastroenterology & Hepatology
  • Methods & Protocols
  • Pathology & Pathobiology
  • Urology

• Earth & Environment

  • Earth sciences
  • Evolution & Ecology

• Life sciences

  • Biotechnology
  • Cancer
  • Development
  • Drug discovery
  • Evolution & Ecology
  • Genetics
  • Immunology
  • Medical research
  • Methods & Protocols
  • Microbiology
  • Molecular cell biology
  • Neuroscience
  • Pharmacology
  • Systems biology

• Physical sciences

  • Physics
  • Materials

by A - Z Index