News and Views
Nature Immunology 9, 223 - 225 (2008)
doi:10.1038/ni0308-223
Basophils: in the spotlight at last
- Booki Min is in the Department of Immunology at the Lerner Research Institute of the Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
- William E. Paul is with the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. e-mail: wpaul@niaid.nih.gov
Abstract
Basophils have long been suspected to be potent inducers of T helper type 2 differentiation. Sokol and colleagues now demonstrate that basophils are required for adoption of the T helper type 2 fate in vivo in response to allergens with protease activity.
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