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Nature Immunology 9, 122–124 (1 February 2008) | doi:10.1038/ni0208-122
CD160 and BTLA: LIGHTs out for CD4+ T cells
Abstract
The T cell costimulatory protein LIGHT and coinhbitory protein BTLA share a common ligand, HVEM. Now CD160 is also shown to bind HVEM and deliver a potent inhibitory signal to CD4 T cells. Although the T cell antigen receptor (TCR) is responsible for imparting specificity to the initial activation of the cell, it is the assortment of additional cell surface proteins acting in a non–antigen-specific way that is central to the regulation of both the quantitative and qualitative aspects of the cell's response. Such modifiers can act in either a positive or a negative way in conjunction with TCR-mediated activation and thus have been called 'costimulators' or 'coinhibitors', respectively.
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