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Lymphocyte transmigration in the brain: a new way of thinking

Lymphocytes depend on endothelial adhesion molecules such as ICAM-1 and VCAM-1, upregulated with inflammation, to facilitate transmigration across junctional barriers. New data show that ALCAM replaces VCAM-1 in the CNS during the development of neuroinflammatory diseases such as multiple sclerosis.

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Figure 1: ALCAM replaces VCAM-1 during transmigration across CNS endothelium.

Katie Ris-Vicari

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Lee, BL., Imhof, B. Lymphocyte transmigration in the brain: a new way of thinking. Nat Immunol 9, 117–118 (2008). https://doi.org/10.1038/ni0208-117

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