Article abstract
Nature Immunology 9, 155 - 165 (2008)
Published online: 13 January 2008 | doi:10.1038/ni1557
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
Heather D Hickman1, Kazuyo Takeda1, Cara N Skon1, Faith R Murray1, Scott E Hensley1, Joshua Loomis2, Glen N Barber2, Jack R Bennink1 & Jonathan W Yewdell1
Abstract
It is uncertain how antiviral lymphocytes are activated in draining lymph nodes, the site where adaptive immune responses are initiated. Here, using intravital microscopy we show that after infection of mice with vaccinia virus (a large DNA virus) or vesicular stomatitis virus (a small RNA virus), virions drained to the lymph node and infected cells residing just beneath the subcapsular sinus. Naive CD8+ T cells rapidly migrated to infected cells in the peripheral interfollicular region and then formed tight interactions with dendritic cells, leading to complete T cell activation. Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation.
- Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
- Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA.
Correspondence to: Jonathan W Yewdell1 e-mail: jyewdell@mail.nih.gov
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Crystal structure of the CDK4/6 inhibitory protein p18 INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16 INK4 mutationsNature Structural Biology Article (01 Jan 1998)
Visualizing priming of virus-specific CD8 + T cells by infected dendritic cells in vivoNature Immunology Article (01 Mar 2002)
Cross-priming of CD8 + T cells stimulated by virus-induced type I interferonNature Immunology Article (01 Oct 2003)
Loading of oncolytic vesicular stomatitis virus onto antigen-specific T cells enhances the efficacy of adoptive T-cell therapy of tumorsGene Therapy Original Article
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activationNature Immunology Article (01 Mar 2008)
See all 18 matches for Research
