News and Views
Nature Immunology 9, 121 - 122 (2008)
doi:10.1038/ni0208-121
What turns on Foxp3?
Harald von Boehmer1 & Jens Nolting1
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Harald von Boehmer and Jens Nolting are with the Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
e-mail: harald_von_boehmer@dfci.harvard.edu
Abstract
Inducible regulatory T cells respond to TGF-
by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF- regulates Foxp3 expression.
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