News and Views
Nature Immunology 9, 119 - 120 (2008)
doi:10.1038/ni0208-119
Stress gets under your skin
Daniel M Andrews1 & Mark J Smyth1
- Daniel M. Andrews and Mark J. Smyth are with the Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. e-mail: mark.smyth@petermac.org
Abstract
The prevailing paradigms ascribe the initiation of immune surveillance to the detection of foreign or inflammatory 'danger' signals. However, new work indicates that immune cells can detect early signs of cellular dysregulation that precede tumorigenesis, even in the absence of non-self signals and/or inflammation.
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