News and Views
Nature Immunology 9, 117 - 118 (2008)
doi:10.1038/ni0208-117
Lymphocyte transmigration in the brain: a new way of thinking
Boris P-L Lee1 & Beat A Imhof1
- Boris P.-L. Lee and Beat A. Imhof are in the Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva 4, CH-1211, Switzerland. e-mail: beat.imhof@medecine.unige.ch
Abstract
Lymphocytes depend on endothelial adhesion molecules such as ICAM-1 and VCAM-1, upregulated with inflammation, to facilitate transmigration across junctional barriers. New data show that ALCAM replaces VCAM-1 in the CNS during the development of neuroinflammatory diseases such as multiple sclerosis.
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