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Nature Immunology 9, 1325 - 1327 (2008)
doi:10.1038/ni1208-1325
Self-termination of the terminator
David Wallach1 & Andrew Kovalenko1
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David Wallach and Andrew Kovalenko are in the Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
e-mail: d.wallach@weizmann.ac.il
Abstract
The protein kinase NIK is regulated by a complex of ubiquitin ligases that destroys it. When NIK-activating receptors are triggered, the ubiquitin ligase complex self-destructs.
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