Article abstract
Nature Immunology 9, 1425 - 1432 (2008)
Published online: 26 October 2008 | doi:10.1038/ni.1664
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
Safia Deddouche1, Nicolas Matt1, Aidan Budd2, Stefanie Mueller1, Cordula Kemp1, Delphine Galiana-Arnoux1,4, Catherine Dostert1,4, Christophe Antoniewski3, Jules A Hoffmann1 & Jean-Luc Imler1
Abstract
Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I–like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.
- Unité Propre de Recherché 9022, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
- European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
- Department of Developmental Biology, Centre National de la Recherche Scientifique URA2578, Institut Pasteur, 75724 Paris, France.
- Present addresses: Institute of Functional Genomics of Lyon–Unités Mixtes de Recherche 5242, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 07, France (D.G.-A.) and Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland (C.D.).
Correspondence to: Jean-Luc Imler1 e-mail: jl.imler@ibmc.u-strasbg.fr
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