Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Immunology 9, 1213 (1 November 2008) | doi:10.1038/ni1108-1213
Research Highlights
Abstract
Terminating LPS 'tolerance' After encountering microbial products such as the Toll-like receptor 4 (TLR4) ligand lipopolysaccharide (LPS), macrophages undergo temporary 'reprogramming' that results in less release of proinflammatory mediators after subsequent microbial stimulation. In Cell Host & Microbe, Lu et al. show that the lipase acyloxyacyl hydrolase (AOAH), which removes secondary acyl chains required for the LPS stimulatory ability, ends this period of LPS 'tolerance'.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
