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Nature Immunology 9, 1210–1212 (1 November 2008) | doi:10.1038/ni1108-1210
IFN-|[gamma]| and self-absorbed CD4+ T cells: a regulatory double negative
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Abstract
Autophagy, an internal cellular degradation process activated in response to nutrient or growth-factor starvation, begins with the formation of an 'autophagosome', an intracellular membrane that engulfs portions of cytoplasm. After fusion with late endosomes or lysosomes, the contents of the fused autophagolysosome are degraded and recycled for the anabolic needs of the cell.
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