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Nature Immunology 9, 1207–1208 (1 November 2008) | doi:10.1038/ni1108-1207

Immunodeficiency: when T cells are stuck at home

Kristin A Hogquist

The cataract Shionogi (CTS) strain of mouse was initially described in 1968 as having cataracts and micropthalmia and was later reported to have profound peripheral T cell deficiency (Ptcd). The nature of this defect, however, has remained unclear.