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Nature Immunology 9, 1210 - 1212 (2008)
doi:10.1038/ni1108-1210
IFN-
and self-absorbed CD4+ T cells: a regulatory double negative
David Hildeman1 & Edith Janssen2
-
Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.
e-mail: hilsv5@cchmc.org - Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA.
Abstract
Interferon-
exerts many effects on the immune system. A new report shows that it induces both autophagy and Irgm1, a GTPase that protects activated CD4+ T cells from executing autophagy.
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