News and Views
Nature Immunology 9, 1097 - 1099 (2008)
doi:10.1038/ni1008-1097
RAPping production of type I interferon in pDCs through mTOR
Mauro Costa-Mattioli1,2 & Nahum Sonenberg1
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Mauro Costa-Mattioli and Nahum Sonenberg are with the Department of Biochemistry and the McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada.
e-mail: nahum.sonenberg@mcgill.ca - Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Abstract
The production of type I interferon—the first line of defense against virus infection and critical for innate immunity—in plasmacytoid dendritic cells relies on the mammalian target of rapamycin.
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