Review abstract
Nature Immunology 9, 1105 - 1111 (2008)
Published online: 18 September 2008 | doi:10.1038/ni.f.215
Shouts, whispers and the kiss of death: directional secretion in T cells
Morgan Huse1, Emily J Quann1 & Mark M Davis2
Abstract
T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor–mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for this synaptic secretion and have also shown that T cells release chemokines and certain inflammatory factors through a multidirectional pathway directed away from the synapse. Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule.
- Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
- Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
Correspondence to: Morgan Huse1 e-mail: husem@mskcc.org
Correspondence to: Mark M Davis2 e-mail: mdavis@pmgm2.stanford.edu
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