Article abstract


Nature Immunology 9, 1179 - 1188 (2008)
Published online: 7 September 2008 | doi:10.1038/ni.1651

Mincle is an ITAM-coupled activating receptor that senses damaged cells

Sho Yamasaki1, Eri Ishikawa1, Machie Sakuma1, Hiromitsu Hara2, Koji Ogata3 & Takashi Saito1,4


Macrophage-inducible C-type lectin (Mincle) is expressed mainly in macrophages and is induced after exposure to various stimuli and stresses. Here we show that Mincle selectively associated with the Fc receptor common gamma-chain and activated macrophages to produce inflammatory cytokines and chemokines. Mincle-expressing cells were activated in the presence of dead cells, and we identified SAP130, a component of small nuclear ribonucloprotein, as a Mincle ligand that is released from dead cells. To investigate whether Mincle is required for normal responses to cell death in vivo, we induced thymocyte death by irradiating mice and found that transient infiltration of neutrophils into the thymus could be blocked by injection of Mincle-specific antibody. Our results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue.

Top
  1. Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  2. Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
  3. Centre for Computational Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  4. World Premier International Immunology Frontier Research Center, Osaka University, Suita, 565-0871, Japan.

Correspondence to: Takashi Saito1,4 e-mail: saito@rcai.riken.jp

Correspondence to: Sho Yamasaki1 e-mail: sho@rcai.riken.jp



MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Sensing necrosis with Mincle

Nature Immunology News and Views (01 Oct 2008)

All roads lead to CARD9

Nature Immunology News and Views (01 Jun 2007)

See all 3 matches for News And Views