Article abstract
Nature Immunology 8, 942 - 949 (2007)
Published online: 5 August 2007 | doi:10.1038/ni1496
Interleukins 1
and 6 but not transforming growth factor- are essential for the differentiation of interleukin 17–producing human T helper cells
Eva V Acosta-Rodriguez1, Giorgio Napolitani1, Antonio Lanzavecchia1 & Federica Sallusto1
Abstract
Interleukin 17 (IL-17)–producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-
and IL-6 and the transcription factor ROR
t. We report here that for human naive CD4+ T cells, RORt expression and TH-17 polarization were induced by IL-1 and enhanced by IL-6 but were suppressed by transforming growth factor- and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1 and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
- Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.
Correspondence to: Federica Sallusto1 e-mail: federica.sallusto@irb.unisi.ch
Correspondence to: Eva V Acosta-Rodriguez1 e-mail: eva.acosta@irb.unisi.ch
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