Article abstract
Nature Immunology 8, 921 - 930 (2007)
Published online: 29 July 2007 | doi:10.1038/ni1495
Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses
Stéphanie Hugues1,2,5, Alix Scholer1,2,5, Alexandre Boissonnas1,2, Alexander Nussbaum1,2, Christophe Combadière3, Sebastian Amigorena1,2 & Luc Fetler1,4
Abstract
Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in search of cognate complexes of peptide in major histocompatibility molecules. However, T cell migration ceases after recognition of cognate antigen. We show here that during the initiation of antigen-specific CD8+ T cell responses, naive CD8+ polyclonal T cells 'preferentially' interacted in an antigen-independent way with mature dendritic cells competent to present antigen to antigen-specific CD8+ T cells. These antigen-independent interactions required expression of the chemokine receptor CCR5 on polyclonal T cells and increased the efficiency of the induction of naive, low-precursor-frequency CD8+ T cell responses. Thus, antigen-specific CD8+ T cells favor the priming of naive CD8+ T cells by promoting the CCR5-dependent recruitment of polyclonal CD8+ T cells to mature dendritic cells.
- Institut Curie, Centre de Recherche, Paris F-75248, France.
- Institut National de la Santé et de la Recherche Médical U653, Immunité et Cancer, Institut Curie, Paris F-75248, France.
- Institut National de la Santé et de la Recherche Médical U543, Laboratoire d'Immunologie Cellulaire, Hôpital Pitié-Salpétrière, Paris, F-75013, France.
- Centre National de la Recherche Scientifique UMR 168, Laboratoire Physico-Chimie Curie, Institut Curie, Paris F-75248, France.
- These authors contributed equally to this work.
Correspondence to: Sebastian Amigorena1,2 e-mail: sebastian.amigorena@curie.fr
Correspondence to: Luc Fetler1,4 e-mail: luc.fetler@curie.fr
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