News and Views
Nature Immunology 8, 795 - 796 (2007)
doi:10.1038/ni0807-795
SWI-SNF: promoter of accessibility
Andrea L Bredemeyer1 & Barry P Sleckman1
- Andrea L Bredemeyer and Barry P. Sleckman are in the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: sleckman@immunology.wustl.edu
Abstract
Time- and tissue-specific recombination of antigen-receptor genes is regulated in part by locus accessibility. New evidence demonstrates a specific function for nucleosome remodeling in the T cell receptor-
locus to allow recombination in thymocytes.
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