Making the most of mouse models - p657

doi:10.1038/ni0707-657

Full Text - Making the most of mouse models | PDF (273 KB) - Making the most of mouse models

Precis on forward genetics in mice - pp659 - 664

Bruce Beutler, Xin Du & Yu Xia

doi:10.1038/ni0707-659

Full Text - Precis on forward genetics in mice | PDF (226 KB) - Precis on forward genetics in mice | Supplementary information

Vagaries of conditional gene targeting - pp665 - 668

Marc Schmidt-Supprian & Klaus Rajewsky

doi:10.1038/ni0707-665

Full Text - Vagaries of conditional gene targeting | PDF (410 KB) - Vagaries of conditional gene targeting

New tools for defining the 'genetic background' of inbred mouse strains - pp669 - 673

William M Ridgway, Barry Healy, Luc J Smink, Dan Rainbow & Linda S Wicker

doi:10.1038/ni0707-669

Full Text - New tools for defining the 'genetic background' of inbred mouse strains | PDF (389 KB) - New tools for defining the 'genetic background' of inbred mouse strains

TLRs bent into shape - pp675 - 677

You-Me Kim, Melanie M Brinkmann & Hidde L Ploegh

doi:10.1038/ni0707-675

Full Text - TLRs bent into shape | PDF (255 KB) - TLRs bent into shape

See also: Article by Latz et al.

Somatic hypermutation is a matter of choice - pp677 - 679

Daniel Bolland & Anne Corcoran

doi:10.1038/ni0707-677

Full Text - Somatic hypermutation is a matter of choice | PDF (172 KB) - Somatic hypermutation is a matter of choice

See also: Article by Fraenkel et al.

Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunity - pp679 - 681

David W O'Neill & Nina Bhardwaj

doi:10.1038/ni0707-679

Full Text - Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunity | PDF (916 KB) - Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunity

See also: Article by Guarda et al. | Article by Fazilleau et al.

Epigenetic regulation of Ifng expression - pp681 - 683

Charalampos G Spilianakis & Richard A Flavell

doi:10.1038/ni0707-681

Full Text - Epigenetic regulation of Ifng expression | PDF (402 KB) - Epigenetic regulation of Ifng expression

See also: Article by Chang & Aune | Article by Schoenborn et al.

Research Highlights - p685

doi:10.1038/ni0707-685

Full Text - Research Highlights | PDF (83 KB) - Research Highlights

T cell development: better living through chromatin - pp687 - 694

Michael S Krangel

doi:10.1038/ni1484

Abstract - T cell development: better living through chromatin | Full Text - T cell development: better living through chromatin | PDF (572 KB) - T cell development: better living through chromatin

Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population - pp695 - 704

Anja Hoffmann, Sheena Kerr, Julia Jellusova, Jiquan Zhang, Florian Weisel, Ute Wellmann, Thomas H Winkler, Burkhard Kneitz, Paul R Crocker & Lars Nitschke

doi:10.1038/ni1480

Abstract - Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population | Full Text - Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population | PDF (675 KB) - Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population | Supplementary information

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR - pp705 - 714

Stella Maris Ranuncolo, Jose M Polo, Jamil Dierov, Michael Singer, Tracy Kuo, John Greally, Roland Green, Martin Carroll & Ari Melnick

doi:10.1038/ni1478

Abstract - Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR | Full Text - Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR | PDF (318 KB) - Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR | Supplementary information

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin -chain locus - pp715 - 722

Shira Fraenkel, Raul Mostoslavsky, Tatiana I Novobrantseva, Roberta Pelanda, Jayanta Chaudhuri, Gloria Esposito, Steffen Jung, Frederick W Alt, Klaus Rajewsky, Howard Cedar & Yehudit Bergman

doi:10.1038/ni1476

Abstract - Allelic 'choice' governs somatic hypermutation : in vivo: at the immunoglobulin [kappa]-chain locus | Full Text - Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin -chain locus | PDF (395 KB) - Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin -chain locus | Supplementary information

See also: News and Views by Bolland & Corcoran

Dynamic changes in histone-methylation 'marks' across the locus encoding interferon- during the differentiation of T helper type 2 cells - pp723 - 731

Shaojing Chang & Thomas M Aune

doi:10.1038/ni1473

Abstract - Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-[gamma] during the differentiation of T helper type 2 cells | Full Text - Dynamic changes in histone-methylation 'marks' across the locus encoding interferon- during the differentiation of T helper type 2 cells | PDF (260 KB) - Dynamic changes in histone-methylation 'marks' across the locus encoding interferon- during the differentiation of T helper type 2 cells | Supplementary information

See also: News and Views by Spilianakis & Flavell | Article by Schoenborn et al.

Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon- - pp732 - 742

Jamie R Schoenborn, Michael O Dorschner, Masayuki Sekimata, Deanna M Santer, Maria Shnyreva, David R Fitzpatrick, John A Stamatoyannopoulos & Christopher B Wilson

doi:10.1038/ni1474

Abstract - Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-[gamma] | Full Text - Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon- | PDF (937 KB) - Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon- | Supplementary information

See also: News and Views by Spilianakis & Flavell | Article by Chang & Aune

L-selectin-negative CCR7^- effector and memory CD8⁺ T cells enter reactive lymph nodes and kill dendritic cells - pp743 - 752

Greta Guarda, Miroslav Hons, Silvia F Soriano, Alex Y Huang, Rosalind Polley, Alfonso Martín-Fontecha, Jens V Stein, Ronald N Germain, Antonio Lanzavecchia & Federica Sallusto

doi:10.1038/ni1469

Abstract - L-selectin-negative CCR7: -: effector and memory CD8: +: T cells enter reactive lymph nodes and kill dendritic cells | Full Text - L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells | PDF (513 KB) - L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells | Supplementary information

See also: News and Views by O'Neill & Bhardwaj

Lymphoid reservoirs of antigen-specific memory T helper cells - pp753 - 761

Nicolas Fazilleau, Michael D Eisenbraun, Laurent Malherbe, Jessica N Ebright, Rebecca R Pogue-Caley, Louise J McHeyzer-Williams & Michael G McHeyzer-Williams

doi:10.1038/ni1472

Abstract - Lymphoid reservoirs of antigen-specific memory T helper cells | Full Text - Lymphoid reservoirs of antigen-specific memory T helper cells | PDF (844 KB) - Lymphoid reservoirs of antigen-specific memory T helper cells | Supplementary information

See also: News and Views by O'Neill & Bhardwaj

IgE^b immune complexes activate macrophages through FcRIV binding - pp762 - 771

Masayuki Hirano, Randall S Davis, W David Fine, Shugo Nakamura, Kentaro Shimizu, Hirokazu Yagi, Koichi Kato, Robert P Stephan & Max D Cooper

doi:10.1038/ni1477

Abstract - IgE: b: immune complexes activate macrophages through Fc[gamma]RIV binding | Full Text - IgEb immune complexes activate macrophages through FcRIV binding | PDF (392 KB) - IgEb immune complexes activate macrophages through FcRIV binding | Supplementary information

Ligand-induced conformational changes allosterically activate Toll-like receptor 9 - pp772 - 779

Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M Sirois, Dionne C G Klein, Brian G Monks, C James McKnight, Marc S Lamphier, W Paul Duprex, Terje Espevik & Douglas T Golenbock

doi:10.1038/ni1479

Abstract - Ligand-induced conformational changes allosterically activate Toll-like receptor 9 | Full Text - Ligand-induced conformational changes allosterically activate Toll-like receptor 9 | PDF (442 KB) - Ligand-induced conformational changes allosterically activate Toll-like receptor 9 | Supplementary information

See also: News and Views by Kim et al.

Corrigendum: Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation - p780

Andrew T Miller, Mark Sandberg, Yina H Huang, Michael Young, Susan Sutton, Karsten Sauer & Michael P Cooke

doi:10.1038/ni0707-780a

Full Text - Corrigendum: Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation | PDF (223 KB) - Corrigendum: Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation

Corrigendum: Toll-like receptor 9—dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE - p780

Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas Golenbock, Cherilyn Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K Crow, Katherine A Fitzgerald, Eicke Latz, Peter A Kiener & Anthony J Coyle

doi:10.1038/ni0707-780b

Full Text - Corrigendum: Toll-like receptor 9—dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE | PDF (223 KB) - Corrigendum: Toll-like receptor 9—dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Erratum: Local increase in thymic stomal lymphopoietin induces systemic alterations in B cell development - p780

Alexander Astrakhan, Miyuki Omori, Thuc Nguyen, Shirly Becker-Herman, Masanori Iseki, Theingi Aye, Kelly Hudkins, James Dooley, Andrew Farr, Charles E Alpers, Steven F Ziegler & David J Rawlings

doi:10.1038/ni0707-780c

Full Text - Erratum: Local increase in thymic stomal lymphopoietin induces systemic alterations in B cell development | PDF (223 KB) - Erratum: Local increase in thymic stomal lymphopoietin induces systemic alterations in B cell development