Article abstract
Nature Immunology 8, 743 - 752 (2007)
Published online: 27 May 2007 | doi:10.1038/ni1469
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
Greta Guarda1, Miroslav Hons1, Silvia F Soriano2, Alex Y Huang3,4, Rosalind Polley3, Alfonso Martín-Fontecha1, Jens V Stein2, Ronald N Germain3, Antonio Lanzavecchia1 & Federica Sallusto1
Abstract
T lymphocytes lacking the lymph node–homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.
- Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.
- Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland.
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
- Present address: Division of Pediatric Hematology/Oncology, Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Correspondence to: Federica Sallusto1 e-mail: federica.sallusto@irb.unisi.ch
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