Commentary
Nature Immunology 8, 669 - 673 (2007)
doi:10.1038/ni0707-669
New tools for defining the 'genetic background' of inbred mouse strains
William M Ridgway1, Barry Healy2, Luc J Smink2, Dan Rainbow2 & Linda S Wicker2
- William M. Ridgway is in the Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15218, USA. e-mail: ridgway2+@pitt.edu
- Barry Healy, Luc J. Smink, Dan Rainbow and Linda S. Wicker are in the Juvenile Diabetes Research Foundation/Wellcome Trust, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. e-mail: linda.wicker@cimr.cam.ac.uk
Abstract
There is general appreciation that 'genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to genetic background effects is outmoded and that new databases containing single-nucleotide polymorphisms obtained with a group of inbred mouse strains can be used to define the flanking DNA of nearly all mouse genes.
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