Supplementary information
From the following article
Igor B Rogozin, Lakshminarayan M Iyer, Lizhi Liang, Galina V Glazko, Victoria G Liston, Youri I Pavlov, L Aravind & Zeev Pancer
Nature Immunology 8, 647 - 656 (2007) Published online: 29 April 2007
doi:10.1038/ni1463
Supplementary Fig. 1
Database of translated genomic VLRA cassettes and their sequence logos.
Supplementary Fig. 2
Database of translated genomic VLRB cassettes and their sequence logos.
Supplementary Fig. 4
Database of 194 mature VLRA sequences aligned to the corresponding genomic cassettes.
Supplementary Fig. 5
Database of 636 mature VLRB sequences aligned to the corresponding genomic cassettes (as in Supplementary Fig. 4).
Supplementary Fig. 6
The sea lamprey cytosine deaminase genes.
Supplementary Fig. 7
Alignment of the AID-APOBEC family with members of the cytosine deaminase superfamily.
Supplementary Fig. 8
In vitro mutagenesis of beta-galactosidase by co-expressed PmCDA1.
Supplementary Table 1
Mutagenic effect of PmCDA1 expression in ung+ or ung- E. coli.
Supplementary Table 2
Spectra of spontaneous and PmCDA1-induced mutations: i) in lacZ in vitro, ii) in E. coli rpoB in vivo, and iii) in S. cerevisiae can1 in vivo.
Supplementary Table 3
Mutagenic effect of PmCDA1 expression in ung+ or ung- S. cerevisiae.
Supplementary Table 4
Induction of intragenic recombination in yeast diploids by PmCDA1.
Supplementary Table 5
Sequence and location of PCR primers.
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