Epithelial NF-κB preserves the integrity of the gut epithelial barrier and coordinates the antimicrobial actions of the innate and adaptive immune systems. Deficiency in or hyperactivation of this transcription factor results in chronic inflammatory bowel disease.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs
Acta Veterinaria Scandinavica Open Access 02 March 2013
-
Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways
BMC Microbiology Open Access 19 March 2012
-
Differential patterns of histone acetylation in inflammatory bowel diseases
Journal of Inflammation Open Access 27 January 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Meylan, E., Tschopp, J. & Karin, M. Nature 442, 39–44 (2006).
Lavon, I. et al. Nat. Med. 6, 573–577 (2000).
Zaph, C. et al. Nature 446, 552–556 (2007).
Nenci, A. et al. Nature 446, 557–561 (2007).
Neish, A.S. et al. Science 289, 1560–1563 (2000).
Lee, J. et al. Nat. Cell Biol. 8, 1327–1336 (2006).
Chen, L.W., et al. Nat. Med. 9, 575–581 (2003).
Liu, Y.J. et al. Annu. Rev. Immunol. 25, 193–219 (2007).
Strober, W., Murray, P.J., Kitani, A. & Watanabe, T. Nat. Rev. Immunol. 6, 9–20 (2006).
Reddy, A. & Fried, B. Parasitol. Res. 100, 921–927 (2007).
Fellermann, K. et al. Am. J. Hum. Gen. 79, 439–448 (2006).
Orange, J.S., Levy, O. & Geha, R.S. Immunol. Rev. 203, 21–37 (2005).
Hermiston, M.L. & Gordon, J.I. Science 270, 1203–1207 (1995).
Pikarsky, E. & Ben-Neriah, Y. Eur. J. Cancer 42, 779–784 (2006).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Ben-Neriah, Y., Schmidt-Supprian, M. Epithelial NF-κB maintains host gut microflora homeostasis. Nat Immunol 8, 479–481 (2007). https://doi.org/10.1038/ni0507-479
Issue Date:
DOI: https://doi.org/10.1038/ni0507-479
This article is cited by
-
Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs
Acta Veterinaria Scandinavica (2013)
-
Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways
BMC Microbiology (2012)
-
PPARγ is an E3 ligase that induces the degradation of NFκB/p65
Nature Communications (2012)
-
Differential patterns of histone acetylation in inflammatory bowel diseases
Journal of Inflammation (2011)
-
Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-κB and Nrf2 in intestinal mucosa of mice
European Journal of Nutrition (2011)