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May 2007 Volume 8 No 5

As a nudge produces a cascade of toppling dominos, a transcription factor initiates a series of cellular processes that subsequently direct lymphocyte lineage differentiation. The resulting lineage identity is malleable, however, sometimes 'bending' with changes in the lineage specification factors present. In a series of specially commissioned articles this month, we focus on transcription factors that influence lymphocyte lineage specification. These pieces and additional material are available free online (www.nature.com/ni/focus/lymphocytespecification/index.html) during May 2007. Artwork by Lewis Long.

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