Review abstract
Nature Immunology 8, 451 - 456 (2007)
Published online: 17 April 2007 | doi:10.1038/ni1453
Regulation of lymphocyte development by Notch signaling
Kenji Tanigaki1 & Tasuku Honjo2
Abstract
Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiation of thymocytes and peripheral T cells, as well as B cells. Here we highlight parallels in the developmental regulation of mammalian lymphocytes and the D. melanogaster nervous system through Notch cooperation with the transcriptional regulators RBP-J (Su(H)), MINT (Hairless) and E2A (Ac-Sc–Da).
- Research Institute, Shiga Medical Center, 5-4-30 Moriyama, Moriyama-shi, Shiga 524-8524 Japan.
- Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku Kyoto, 606-8501 Japan.
Correspondence to: Tasuku Honjo2 e-mail: honjo@mfour.med.kyoto-u.ac.jp
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