1. Rashu B. Seth and Zhijian J. Chen are with the Howard Hughes Medical Institute and Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. e-mail: zhijian.chen@utsouthwestern.edu

Abstract

Smad7 controls inflammation by negatively regulating activation of the transcription factor NF-B. New work shows that Smad7 inhibits NF-B by binding to the regulatory proteins TAB2 and TAB3, thereby blocking association of the E3 ubiquitin ligase TRAF2 with the kinase TAK1.

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