1. Takashi Nomura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. e-mail: shimon@frontier.kyoto-u.ac.jp

Abstract

The transcriptional regulators Foxp3 and Aire have key functions in self-tolerance. New studies emphasize potential links between Aire-expressing thymic stromal cells and the development of Foxp3-expressing regulatory T cells.

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