News and Views
Nature Immunology 8, 333 - 334 (2007)
doi:10.1038/ni0407-333
Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance
Takashi Nomura1 & Shimon Sakaguchi1
- Takashi Nomura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. e-mail: shimon@frontier.kyoto-u.ac.jp
Abstract
The transcriptional regulators Foxp3 and Aire have key functions in self-tolerance. New studies emphasize potential links between Aire-expressing thymic stromal cells and the development of Foxp3-expressing regulatory T cells.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Knowing one's self: central tolerance revisitedNature Immunology News and Views (01 Apr 2003)
Policing the regulatorsNature Immunology News and Views (01 Apr 2001)
See all 5 matches for News And ViewsRESEARCH
Selection of Foxp3 + regulatory T cells specific for self antigen expressed and presented by Aire + medullary thymic epithelial cellsNature Immunology Article (01 Apr 2007)
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2Nature Immunology Article (01 Feb 2005)
See all 31 matches for Research