News and Views


Nature Immunology 8, 234 - 236 (2007)
doi:10.1038/ni0307-234

Claudins provide a breath of fresh Aire

Georg A Holländer1

  1. Georg A. Holländer is with the Laboratory of Pediatric Immunology at the Centre for Biomedicine, the Department of Clinical-Biological Sciences and The University Children's Hospital, University of Basel, 4058 Basel, Switzerland. e-mail: georg-a.hollaender@unibas.ch


'Promiscuous' gene expression in medullary thymic epithelial cells positive for the autoimmune regulator Aire is critical for central T cell tolerance. Expression of the tight-junction components claudin-3 and claudin-4 'marks' Aire+ epithelial cells in the postnatal thymus and their direct precursors in the embryo.

Top

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Dead man walking: how thymocytes scan the medulla

Nature Immunology News and Views (01 Aug 2009)

Immunology A second chance for the thymus

Nature News and Views (22 Jun 2006)

See all 5 matches for News And Views

Extra navigation

Subscribe to Nature Immunology

Subscribe

Search PubMed for

Open Innovation Challenges

  • Optimizing Sub-cellular Localization Tags

    • Deadline: Jan 31 2010
    • Reward: $20,000 USD

    The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....

  • Single-cell Analysis Platform

    • Deadline: Dec 02 2009
    • Reward: $5,000 USD

    This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...

ADVERTISEMENT