News and Views
Nature Immunology 8, 234 - 236 (2007)
doi:10.1038/ni0307-234
Claudins provide a breath of fresh Aire
Georg A Holländer1
- Georg A. Holländer is with the Laboratory of Pediatric Immunology at the Centre for Biomedicine, the Department of Clinical-Biological Sciences and The University Children's Hospital, University of Basel, 4058 Basel, Switzerland. e-mail: georg-a.hollaender@unibas.ch
Abstract
'Promiscuous' gene expression in medullary thymic epithelial cells positive for the autoimmune regulator Aire is critical for central T cell tolerance. Expression of the tight-junction components claudin-3 and claudin-4 'marks' Aire+ epithelial cells in the postnatal thymus and their direct precursors in the embryo.
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