Article abstract
Nature Immunology 8, 181 - 190 (2006)
Published online: 31 December 2006 | doi:10.1038/ni1427
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self
Je-Wook Lee1, Mathieu Epardaud1,2, Jing Sun1, Jessica E Becker1, Alexander C Cheng1, Ai-ris Yonekura1,3, Joan K Heath4 & Shannon J Turley1,5
Abstract
The intestinal epithelium functions to absorb nutrients and to protect the organism against microbes. To prevent autoimmune attack on this vital tissue, T cell tolerance to intestinal self-antigens must be established. Central tolerance mechanisms involve medullary thymic epithelial cells (mTECs), which use endogenously expressed peripheral-tissue antigens (PTAs) to delete self-reactive thymocytes. The prevailing model for the induction of peripheral tolerance involves cross-presentation of tissue antigens by quiescent dendritic cells. Here we show that lymph node stromal cells present endogenously expressed PTAs to T cells. Moreover, antigen presentation by lymph node stroma is sufficient to induce primary activation and subsequent tolerance among CD8+ T cells. Thus, lymph node stromal cells are functionally akin to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cells.
- Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
- Virologie et Immunologie Moleculaires UR892, INRA, Domaine de Vilvert, F-78352 Jouy-en-Josas, France.
- Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts 02115, USA.
- Ludwig Institute for Cancer Research, Melbourne Branch, Post Office Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.
- Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence to: Shannon J Turley1,5 e-mail: shannon_turley@dfci.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetesNature Immunology Article (01 Sep 2009)
Bone marrow as a priming site for T-cell responses to blood-borne antigenNature Medicine Article (01 Sep 2003)
Direct priming of antiviral CD8 + T cells in the peripheral interfollicular region of lymph nodesNature Immunology Article (01 Feb 2008)
Na???ve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiationNature Immunology Article (01 May 2001)
See all 35 matches for Research
