News and Views
Nature Immunology 8, 119 - 120 (2007)
doi:10.1038/ni0207-119
Shaping a helper T cell identity
Harinder Singh1
- Harinder Singh is in the Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA. e-mail: hsingh@uchicago.edu
Abstract
Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators.
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