Article abstract
Nature Immunology 8, 1363 - 1371 (2007)
Published online: 11 November 2007 | Corrected online: 16 November 2007 | doi:10.1038/ni1537
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Jason S Stumhofer1, Jonathan S Silver1, Arian Laurence2, Paige M Porrett3, Tajie H Harris1, Laurence A Turka3, Matthias Ernst4, Christiaan J M Saris5, John J O'Shea2 & Christopher A Hunter1
Abstract
Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses. Consistent with that activity, many sources of this cytokine are found in vivo, including from myeloid cells and a variety of T cell subsets. However, although there are many pathways that regulate innate production of IL-10, the factors that govern its synthesis by the adaptive response are poorly understood. Here we report that IL-27 and IL-6 induced T helper type 1 and type 2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses.
- Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
- Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Muskoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.
- Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
- Ludwig Institute for Cancer Research, Parkville, Victoria 3050, Australia.
- Department of Inflammation Research, Amgen, Thousand Oaks, California 91320, USA.
Correspondence to: Christopher A Hunter1 e-mail: chunter@vet.upenn.edu
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