Article abstract
Nature Immunology 8, 1345 - 1352 (2007)
Published online: 21 October 2007 | doi:10.1038/ni1524
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
Tiffany Horng1,2, Jelena S Bezbradica1 & Ruslan Medzhitov1
Abstract
The effector functions of natural killer cells are regulated by activating receptors, which recognize stress-inducible ligands expressed on target cells and signal through association with signaling adaptors. Here we developed a mouse model in which a fusion of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells. With this system, we identified coupling of the signaling pathways triggered by NKG2D and DAP10 to those initiated by the interleukin 15 receptor. We suggest that this coupling of activating receptors to other receptor systems could function more generally to regulate cell type–specific signaling events in distinct physiological contexts.
- Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
- Present address: Department of Pathology, Harvard Medical School, Immune Disease Institute, Boston, Massachusetts 02115, USA.
Correspondence to: Tiffany Horng1,2 e-mail: horng@cbrinstitute.org
Correspondence to: Ruslan Medzhitov1 e-mail: ruslan.medzhitov@yale.edu
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